Methionine metabolism in mammals. Adaptation to methionine excess.
نویسندگان
چکیده
منابع مشابه
Adaptation of hepatic enzyme activities to methionine excess.
Two groups of adult male rats 8 weeks old were fed a 10 p. 100 protein (casein) diet with or without 2 p. 100 methionine. After 8 rats in each group were killed at 10 a.m. on experimental days 1, 2, 4, 8 and 21, we studied the profiles of plasma non-esterified fatty acids (NEFA) and of the hepatic activities of pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphate...
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Using an in vitro system which contained enzymes, substrates, and other reactants at concentrations which approximated the in vivo conditions in rat liver, we measured the simultaneous product formation by three enzymes which utilize homocysteine. In the control system, 5-methyltetrahydrofolate homocysteine methyltransferase, betaine homocysteine methyltransferase, and cystathionine beta-syntha...
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Methionine aminopeptidase (MetAP) catalyzes removal of the initiator methionine from nascent polypeptides. In eukaryotes, there are two forms of MetAP, type 1 and type 2, whose combined activities are essential, but whose relative intracellular roles are unclear. Methionine metabolism is an important aspect of cellular physiology, involved in oxidative stress, methylation, and cell cycle. Due t...
متن کاملEffect of Methionine Supplementation on Methionine Metabolism in Growing Cattle
Methionine is often the first limiting amino acid for growing cattle. This study was conducted to determine how methionine metabolism is regulated in the liver of growing steers. Six ruminally cannulated steers were used in a replicated 3 × 3 Latin square experiment. Either 0, 5, or 10 g/day L-methionine was infused into the abomasum. These treatments were designed to be deficient, adequate, an...
متن کاملMethionine metabolism in human pregnancy.
BACKGROUND Hyperhomocysteinemia during pregnancy, which is a consequence of perturbations in methionine and/or folate metabolism, has been implicated in adverse outcomes such as neural tube defects, preeclampsia, spontaneous abortion, and premature delivery. The adaptive changes in methionine metabolism during pregnancy in humans have not been determined. OBJECTIVE Our objective was to examin...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)35979-3